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Pathology is an inherently subjective discipline, and therefore is often referred to as both an art and a science. Over the years, laboratory physicians have implemented special tissue stains and molecular techniques to limit subjectivity in the discipline. Beginning in the late 19th century, histochemical stains were developed to assess diagnostic biochemical reactions in tissue. Histochemistry has recently seen a resurgence in popularity because of the higher costs of other newer methods. Today, this technique is used by almost every pathology laboratory across the world.
This book comprehensively covers all diseases for which that technique plays a central role in diagnosis. Every anatomic region is covered in detail with examples of appropriate staining techniques, and the book is heavily illustrated with over 850 color photomicrographs. This is the first monograph to be published on histochemistry in 15 years, and it is the only one that is diagnostically-oriented.
This volume enables students to master the science and clinical applications of hematologic pathophysiology and develop the problem-solving skills that are needed for exams and clinical rotations. The book provides a solid overview of hematology and applies scientific principles to actual clinical cases and problems. This unique “case-problem” format prepares students to link basic science to clinical medicine as emphasized in today’s exams.Using actual patient cases to illustrate hematologic principles, the book covers the life cycles, structures, and physiology of red and white blood cells and then discusses hemostasis, bone marrow disorders, and hematologic malignancies. Boxed case-problems challenge the student to apply key hematologic principles in a variety of clinical decisions. Numerous two-color drawings and schematics illustrate all essential concepts, and subheads, color highlights, and tables aid in comprehension and review.
a superb summary of the topic, is a modern synthesis of Dameshek’s adventurous thinking. … Myeloproliferative Disorders is an important contribution to hematology. It arrives at a time when the study and treatment of these important diseases is at a crossroads, a time when hematologists everywhere have come to expect that the next great leap forward will come soon. For me, this book will sit on the shelf next to the first edition of Dameshek’s Leukemia. …” (Robert Schwartz, New England Journal of Medicine, 356/ 24, June 2007)
“First identified and named by William Dameshek in 1951, myeloproliferative disorders have become ‘landmarks in the history of malignant disease … on which progress in understanding and treating other malignancies … and indeed solid tumors can be based.’ … it ‘should be of interest to medical students who find the specialty of hematology truly fascinating.’ For other physicians and for patients, this reference provides a needed understanding of avant-garde medical research.” (William H. Wehrmacher, JAMA, Vol. 298, 2007)
The well respected textbook “Pathophysiology: Concepts of Altered Health States” has now been fully adapted for Canadian undergraduate nursing and health professions students. Like the original text, this Canadian edition includes a review of anatomy and physiology and treatment information for commonly occurring disease states. Pediatric, geriatric, and pregnancy deviations are integrated throughout and highlighted with icons for easy identification. Canadian content includes Canadian healthcare statistics regarding incidence; cultural variations, with a focus on native population and largest immigrant populations; Canadian research and researchers; Canadian treatment protocols and guidelines; and commonly occurring disease concerns based on Canadian statistics.
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