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Acute Ischemic Stroke: Imaging and Intervention is a comprehensive presentation of the state-of-the-art in the diagnosis and treatment of acute ischemic stroke. This book, the first of its kind, offers a practical review of recent advances in stroke neuroimaging, and the latest therapeutic options for this disease.
Written by an internationally recognized experts who are members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School, the book covers the pathophysiology, mechanisms and molecular manifestations of ischemic brain injury and its clinical presentations; the physical principles, and practical applications of CT, CT angiography and CT perfusion; a detailed discussion of MRI, MRA, as well as diffusion and perfusion MR imaging; and the clinical management of the acute ischemic stroke patient including intravenous thrombolysis and intra-arterial vascular recanalization.
Practical guidance is provided for the use of imaging in guiding therapeutic decisions efficiently. The book is richly illustrated with images and plentiful tables are available for easy reference. It will serve as a unique source of information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke
This book will show you how to:
The second edition includes three totally new chapters, over 200 more tips, and covers the latest in stroke prevention, medical treatment, and rehabilitation to help survivors transition from being a patient to returning to a life well-lived.
The text that bridges the gap between basic neuroscience and clinical practice – updated with the latest advances and full-color illustrations
For more than twenty years, Clinical Neurology has helped students, residents, and clinicians understand the link between basic neuroscience and current approaches in diagnosis and treatment. Distinguished by its practice-oriented approach to neurology based on presenting symptoms, this trusted classic delivers the clearest and most concise introduction to the field available anywhere.
The book presents 101 cases from adult neurology, paediatric neurology, and neurosurgery practice covering all major neuroradiology topics. Each case begins with one or more high-resolution images, a brief history, and questions, with answers and detailed explanations on the next page.
Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.
Genetic Instabilities and Neurological Diseases covers DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students.
The fifth volume in this series covers emotional behavior and its disorders. The introductory chapters deal with the basic theoretical and anatomical issues in the neuropsychological study of emotions. Both neurobiologically oriented and cognitively oriented theories of emotion are presented and both the detailed anatomo-clinical and theoretical aspects of the anatomical substrates of emotions are covered in depth. The central part of this volume addresses the problem of hemispheric asymmetries in emotional representation. The claims for right hemisphere dominance for emotions and emotional communication are contrasted with those assuming a different hemispheric specialization for positive vs. negative emotions and with models assuming asymmetric cortico-limbic control of human emotion. A final group of chapters examines the neural mechanisms of the stress response and reviews the main emotional disorders. Individual differences in the hemispheric control of the stress response are discussed and the neural mechanisms of affective/emotional disturbances are approached with neuropsychological methods and with functional neuroimaging techniques.
The Handbook of Polygraph Testing examines the fundamental principles behind lie detector tests and provides an up-to-date review of their validity. The editor presents current psychological theories, including an explanation of the cognitive processes central to polygraph testing. He describes the various methods of testing, the research in support of each method, and special issues in polygraph research. The Handbook helps readers interpret existing research studies, and learn how to improve the accuracy of polygraph testing and analysis.
This book offers an overview of topics related to neurobiological impairments which are related to the ageing brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008).
The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson’s and Alzheimer’s, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers.
This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis for growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signalling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signalling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signalling.
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a “better understanding of the epilepsies and seek more rational methods of their prevention and treatment.” Since then, basic and clinical researchers in epilepsy have gathered together every decade
and a half with these goals in mind – assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past
four decades, this fourth edition of Jasper’s BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease
The thoroughly updated Twelfth Edition of this classic retains the organization, practicality, and readability that makes Merritt’s Neurology one of the most popular texts among neurologists, primary care physicians, and residents reviewing for psychiatry or neurology boards. In 183 short chapters, the book provides the essentials clinicians need on symptoms/signs, diagnostic tests, and neurologic disorders of all etiologies.
An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular, with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy.
Fully updated throughout, this popular book explains the history, rationale, and detailed descriptions of the class of soft tissue manipulation methods known collectively as NMT techniques.
This volume tries to link the new concepts and discoveries in the field of sensorimotor coordination. It contains the main contributions of participants of an international symposium held in Lyon in 2001 entitled “Neural control of space coding and action production”. The book emphasizes the reciprocal relationship between perception and action, and the essential role of active sensorimotor organization or reorganization in building up perceptual and motor representations of the self and of the external world.
Progress in genetic knowledge is profoundly affecting medical practice, and no clinical specialty has more diseases associated with genetic mutations than neurology. As a more complete picture of the genes which give rise to neurological disease is obtained, trainee and practising neurologists need a guide to basic principles and the more important clinical entities with a genetic component. It is against this background that Neurogenetics: A Guide for Clinicians has been written. The book opens with coverage of genetic testing and counselling. Subsequent chapters discuss genetic factors for all the major neurological diseases, including epilepsy, Alzheimer’s disease, Parkinsonism and muscular dystrophies. No book in this field can hope to be fully up to date with the latest research; rather this work provides a framework on which to add new genetic discoveries. Neurogenetics: A Guide for Clinicians provides a synoptic overview for neurologists, medical geneticists and scientists working in the field.
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