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Acute Ischemic Stroke: Imaging and Intervention is a comprehensive presentation of the state-of-the-art in the diagnosis and treatment of acute ischemic stroke. This book, the first of its kind, offers a practical review of recent advances in stroke neuroimaging, and the latest therapeutic options for this disease.
Written by an internationally recognized experts who are members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School, the book covers the pathophysiology, mechanisms and molecular manifestations of ischemic brain injury and its clinical presentations; the physical principles, and practical applications of CT, CT angiography and CT perfusion; a detailed discussion of MRI, MRA, as well as diffusion and perfusion MR imaging; and the clinical management of the acute ischemic stroke patient including intravenous thrombolysis and intra-arterial vascular recanalization.
Practical guidance is provided for the use of imaging in guiding therapeutic decisions efficiently. The book is richly illustrated with images and plentiful tables are available for easy reference. It will serve as a unique source of information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke
This book will show you how to:
The second edition includes three totally new chapters, over 200 more tips, and covers the latest in stroke prevention, medical treatment, and rehabilitation to help survivors transition from being a patient to returning to a life well-lived.
From the beginning of the use of chlorpromazine and other neuroleptic drugs, signs of parkinsonism (e.g., tremor, rigidity, and bradykinesia) were observed as frequent side effects and, despite numerous studies to the contrary, were considered to be inextricably linked to therapeutic antipsychotic effects. Within a few years, investigators also observed an association between these drugs and abnormal involuntary movements that came to be known as tardive dyskinesia (TD). These and other drug-induced extrapyramidal side effects (EPS) can be mistaken for or worsen primary psychotic symptoms, are sometimes irreversible or lethal, often necessitate additional burdensome side effects from antiparkinsonian agents, can be disfiguring and stigmatizing, and have been shown to influence compliance, relapse, and rehospitalization. As a result, EPS dominated concerns about tolerability of antipsychotic drugs for decades, and their elimination served as a major impetus for new drug research and development. In 1988, clozapine was found to have broader efficacy in schizophrenia with negligible EPS, stimulating the search for other antipsychotics with improved tolerability. The drugs that were introduced after clozapine came to be known as atypical or second-generation antipsychotics (SGAs) while the earlier drugs were now called typical or first-generation antipsychotics (FGAs). Industry-sponsored clinical trials suggested that SGAs were superior to FGAs in the treatment of schizophrenia, reducing psychotic symptoms and causing fewer EPS. Cumulative evidence supporting reduced liability for EPS with SGAs contributed to the widespread dominance of these drugs in the marketplace and fostered the concept of “atypicality” in the mechanism of action of the new drugs.
Back pain is one of the most common reasons cited by patients seeking medical help, and it is a leading cause of time off work and long term disability. Causes of back pain are complex and many health care professionals devote a substantial amount of their time dealing with it. The initiating event leading to back pain is often compounded by other factors leading to maladaptive behaviour and prolongation of pain. This pocketbook will summarise the current literature on management of back pain and provide evidence-based, practical guidelines for clinicians.
Brain Mapping: A Comprehensive Reference offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty.
Stroke is a major cause of morbidity and mortality, with carotid disease representing an important contributory risk factor. This book offers comprehensive coverage of the pathogenesis and management of carotid disease with specific focus on the role imaging has to play in the early recognition of symptomatic and asymptomatic disease as well as the treatment of the developed condition. Technological advances in imaging modalities now allow detailed analysis of the disease progression, the prediction of critical events leading to a stroke, as well as the identification of the most effective surgical or other interventional treatments. This book should be read by neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists involved in the care of patients with carotid disease, and also by researchers involved in the development of new therapeutic techniques and drugs.Stroke is a major cause of morbidity and mortality, with carotid disease representing an important contributory risk factor. This book offers comprehensive coverage of the pathogenesis and management of carotid disease with specific focus on the role imaging has to play in the early recognition of symptomatic and asymptomatic disease as well as the treatment of the developed condition. It discusses the technological advances in imaging modalities which now allow detailed analysis of the disease progression, the prediction of critical events leading to a stroke, as well as the identification of the most effective surgical or other interventional treatments. Highly illustrated throughout with leading expert contributors, this book should be read by neurologists, cardiologists, vascular surgeons, neurosurgeons and radiologists involved in the care of patients with carotid disease, and also by researchers involved in the development of new therapeutic techniques and drugs.
Case-Based Neurology provides a broad selection of cases drawn from all major areas of neurology including critical care and trauma, epilepsy, movement disorders, stroke, neurodegenerative diseases, spinal cord pathologies, neuro-oncology, neuromuscular and peripheral nervous system disorders, neuro-immunology, and neuro-infectious diseases. As the reader works through the cases, the importance of careful history taking, thorough examination, and ordering appropriate diagnostic studies is reinforced as it becomes apparent that the same chief complaint can lead to totally different diagnoses. Controversies in management are addressed within the case discussions to highlight differences in treatment philosophy and help sharpen clinical acumen.
Features of Case-Based Neurology include:
This profusely illustrated, concise, yet detailed sourcebook enables both neurosurgeons and neurologists to map functions to specific cognitive and sensory locations in the brain. Clinical Brain Mapping takes you step by step through the methods and functional bases of the techniques, focusing on all clinical situations that require cerebral localization for diagnosis and therapeutic management.
Clinical Brain Mapping is cohesively organized into two sections: Techniques and Systems. The first section covers the full scope of methods for determining cerebral location, from the classic Wada test to the newest fMRI and magnetoencephalography procedures. In the Systems section, expert contributors offer key insights into the systems that are mapped with a multi-modality approach, covering somatomotor and somatosensory function, language, vision, hearing, and memory. The book concludes with informative chapters on specific applications of mapping techniques.
This is the first volume to explore the field of clinical magnetoencephalography (MEG) and magnetic source imaging (MSI), the techniques measuring the magnetic fields generated by neuronal activity in the brain. Describing the empirical knowledge gained during the last two decades, this book will serve as a basis for the training of clinicians and scientists entering this new and exciting field. The book covers the methods for recording MEG and performing MSI in a clinical setting and includes practical examples of data collection and analysis. It explains why MEG should be used in the evaluation and treatment of patients being considered for epilepsy surgery, concluding with a section describing the potential for future applications of these methods. This is essential reading for graduate students in clinical neuroscience, residents in neurology and psychiatry, neuroradiology and neurosurgery, specialists in neurophysiology and epilepsy, and clinicians in a wide range of related brain sciences.
The text that bridges the gap between basic neuroscience and clinical practice – updated with the latest advances and full-color illustrations
For more than twenty years, Clinical Neurology has helped students, residents, and clinicians understand the link between basic neuroscience and current approaches in diagnosis and treatment. Distinguished by its practice-oriented approach to neurology based on presenting symptoms, this trusted classic delivers the clearest and most concise introduction to the field available anywhere.
Essentials of Electrodiagnostic Medicine is an intermediate level text for residents, fellows, and practitioners. This practical book is readable in the course of a standard resident rotation and ideal for board exam review, while also comprehensive enough to be a useful reference. The second edition has been thoroughly updated throughout while retaining the key features of the first edition.
Essentials of Electrodiagnostic Medicine is divided into two parts. The first part covers the theoretical and technical fundamentals including basic electronics, instrumentation, and the anatomical, physiological, and pathological underpinnings of electrodiagnostic medicine. The second half of the book is devoted to the clinical applications and electroclinical correlations of the most common diseases and conditions. Each chapter begins with an outline and concludes with a bulleted list of key points and annotated bibliography that succinctly summarizes the relevant literature.
Essentials of Electrodiagnostic Medicine features:
The book presents 101 cases from adult neurology, paediatric neurology, and neurosurgery practice covering all major neuroradiology topics. Each case begins with one or more high-resolution images, a brief history, and questions, with answers and detailed explanations on the next page.
Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.
Genetic Instabilities and Neurological Diseases covers DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students.
The fifth volume in this series covers emotional behavior and its disorders. The introductory chapters deal with the basic theoretical and anatomical issues in the neuropsychological study of emotions. Both neurobiologically oriented and cognitively oriented theories of emotion are presented and both the detailed anatomo-clinical and theoretical aspects of the anatomical substrates of emotions are covered in depth. The central part of this volume addresses the problem of hemispheric asymmetries in emotional representation. The claims for right hemisphere dominance for emotions and emotional communication are contrasted with those assuming a different hemispheric specialization for positive vs. negative emotions and with models assuming asymmetric cortico-limbic control of human emotion. A final group of chapters examines the neural mechanisms of the stress response and reviews the main emotional disorders. Individual differences in the hemispheric control of the stress response are discussed and the neural mechanisms of affective/emotional disturbances are approached with neuropsychological methods and with functional neuroimaging techniques.
The Handbook of Polygraph Testing examines the fundamental principles behind lie detector tests and provides an up-to-date review of their validity. The editor presents current psychological theories, including an explanation of the cognitive processes central to polygraph testing. He describes the various methods of testing, the research in support of each method, and special issues in polygraph research. The Handbook helps readers interpret existing research studies, and learn how to improve the accuracy of polygraph testing and analysis.
This book offers an overview of topics related to neurobiological impairments which are related to the ageing brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008).
The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson’s and Alzheimer’s, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers.
This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
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